Another Company's product
There are a lot of aquarium products on the market, and while most of them will work perfectly fine together in the aquarium, some will not. We can't 100% guarantee any product that's not our own, but here's a few quick rules:
- Avoid using products that overlap in function. Either one works and so it's the one you should be using, both work and so it's a waste to use them both, or neither work and you should be looking for a third, better product.
- Research the products you use carefully. Typically, if a product or medication is volatile enough to react with conditioners like Prime®, the company will mention it on the label or website, or you can call in to check.
- When in doubt, wait a day. A standard dose of Prime® is typically exhausted (is no longer reactive) after 24 hours and breaks down completely after 48 hours. After 24 hours Prime® is likely incapable of reacting with a new product that you add to the water, and after 48 hours you can be certain that there will be no reaction between the two.
Seachem® Products
It's safe to use Prime® alongside any of Seachem®'s products except Cupramine™. If Prime® is added to a tank that contains Cupramine™, it converts the Cupramine™ into a more toxic form. If this happens accidentally, you'll need to remove the Cupramine™ right away using activated filter carbon or CupriSorb™. We recommend avoiding the use of Prime® during treatment with Cupramine™ entirely if possible, but if you need to do a water change, treat the new water with Prime® 48 hours before dosing the Cupramine™ so that the Prime® will be completely exhausted and there is no possibility that it will react with the Cupramine™.
Prime® will not directly interact with any of the other Seachem® products, but a large overdose of reducing agents (conditioners like Prime®, ammonia detoxifiers, stress reducers, and some medications) can start to reduce the oxygen levels of the tank. It's just fine to use multiple reducing agents if you have good filtration and you're not using extra products unnecessarily, but if you need to use 3 or more reducing agents at the same time, it may be best to wait an hour or so between products to avoid a sudden drop in oxygen levels.
Here's some Seachem® products that are considered reducing agents
| Prime® | Betta Basics™ | Clarity® | StressGuard™ |
| Safe® | Gold Basics™ | Neutral Regulator® | ParaGuard™ |
| AmGuard™ |
As previously mentioned, it is fine to use these products together - they will not interact with each other. Just make sure you have good filtration and if you need to use 3 or more, spread your dosing out by an hour or so.
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