Possibly. PolyGuard™ is an exclusively in-water medication that can be stressful to plants and invertebrates (corals, mushrooms, shrimp, crabs, etc.). It should not be used in tanks that contain plants or invertebrates for this reason. If it is necessary to treat this kind of tank for an infection, it is recommended to use either KanaPlex™ or MetroPlex™ in the fish's food to clear out bacterial or fungal infections.
Fish that are more sensitive to medications (scale-less fish, sharks, rays, eels, etc.) should be treated with care. If you are concerned that your fish may be stressed by the use PolyGuard™, we recommend to start with a partial dose (1/4 to 1/2 the recommended dose) and work up to the full dose over time. It is also less stressful on these fish to treat in the fish's food instead of the water.
PolyGuard™ Compatibility Guide
Green: This product is safe for these tank inhabitants. Take care to avoid sudden large shifts in water parameters within the tank, and review the dosing instructions carefully to avoid improper dosing.
Orange: These tank inhabitants are more sensitive, and while the product can still be used on them, it's best to start with a partial dose and work up to the full dose over time.
Red: This product is either notably stressful or utterly unsuitable for these tank inhabitants. It would be best to opt for a different product if possible. Click tank inhabitant name for alternate products.
Black: There should never be any need to use this product in a tank with these tank inhabitants - we have no data as to compatibility for this reason. Click the tank inhabitant name for alternate products.
| Freshwater Community Fish | Saltwater Community Fish | Scale-less fish |
| Sharks | Rays | Eels |
| Freshwater Sharks | Freshwater Rays | Freshwater Eels |
| Loaches | Catfish | Aquatic Frogs |
| Shrimp | Snails | Clams |
| Plants | Corals | Exotic Invertebrates |
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