NOT RECOMMENDED.
These medications do not directly interact with each other, but both ParaGuard™ and SulfaPlex™ address external bacterial infections, so there should never be a need to use both simultaneously. Doubling up on treatments unnecessarily is more likely to stress the fish than help them.
For more information about using the Seachem® medications together, check out FAQ: Can I use the Seachem® medications together?
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