No. Flourish Advance® contains neither buffers nor significant concentrations of calcium and magnesium, so it will have no impact on pH, GH, or KH when used as recommended. If you have laboratory-grade equipment, you may note a slight increase in calcium and magnesium (these are included in the product as essential minerals for plants) but they are not present in high enough concentrations to show up on a standard GH test kit even when grossly overdosed.
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