It certainly is. An overdose of Acid Buffer™ can result in a sudden and stressful shift in pH and KH. If pH or KH of the water is still incorrect despite repeated additions of a buffer like Acid Buffer™, it is likely that there is a high concentration of acids or buffers in the aquarium that are resisting the change in pH.
FAQ: Is it possible to overdose Seachem Acid Buffer™?
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