Another Company's product
There are a lot of aquarium products on the market, and while most of them will work perfectly fine together in the aquarium, some will not. We can't 100% guarantee any product that's not our own, but here's a few quick rules:
- Avoid using products that overlap in function. Either one works and so it's the one you should be using, both work and so it's a waste to use them both, or neither work and you should be looking for a third, better product. In the case of Neutral Regulator®, using multiple buffers and regulators when only one is needed could result in a pH that is different from the one you want.
- Avoid using products that directly contradict each other. Neutral Regulator® is a phosphate based buffer, so filter medias that remove phosphate should not be used with it.
- Research the products you use carefully. Typically, if a product or medication is volatile enough to react with a buffer or regulator, the company will mention it on the label or website, or you can call in to check.
- When in doubt, wait a day. While there should not be any interaction between Neutral Regulator® and another product, leaving 24 hours in between the doses will avoid possible fish stress from rapidly changing water parameters.
Seachem® Products
Neutral Regulator® should not be added to an aquarium that is currently being treated with Cupramine™. Neutral Regulator® contains conditioning agents that could react poorly with this medication, converting the copper in Cupramine™ to a more toxic form. It is perfectly fine to add Cupramine™ to water that was treated with Neutral Regulator® at least 24 hours in advance though, as this will give the conditioning agents time to become exhausted.
It's safe to use Neutral Regulator® alongside any of the other Seachem® products that are recommended for freshwater systems. That said, combining high levels of minerals with phosphate-based buffers like Neutral Regulator® can result in noticeable precipitation. This precipitation is not harmful to fish, but can be unsightly until cleared away using fine filter media (see Clarity® for more info about clearing precipitation)
Among Seachem® products, there are several mineral supplements that are recommended for freshwater community aquariums, but may cause noticeable precipitation if used in high quantities in an aquarium buffered with Neutral Regulator®.
Here's some Seachem® products that are Freshwater Mineral Supplements
| Replenish™ | American Cichlid Salt™ | Equilibrium™ |
| Brackish Salt™ | Cichlid Lake Salt™ |
As previously mentioned, it is fine to use these products together, but high levels of either can result in nontoxic precipitation. We recommend to dose in moderation to avoid this effect.
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